Unlocking the Science of Cellular Nutrition

Unlocking the Science of Cellular Nutrition

Healthy cells power a healthy body. Cellular nutrition is about giving our cells the essential nutrients they need to function at their best. These nutrients act as fuel, building blocks, and protective agents - driving energy production, supporting repair, and strengthening immune defences. (1, 2) Thus, contributing to optimal long-term health.

What Are Cellular Nutrients?

Cellular nutrients include vitamins, minerals, amino acids, fatty acids and antioxidants, all of which are key for supporting our metabolism and cell functions. Not only do these nutrients serve as the building blocks for cellular structure and fuel sources, but they also serve as modifiers of protein function, and act as signalling molecules to support communication between cells (2)

Within almost every cell of the body are mitochondria which act to convert these essential nutrients into energy in the form of Adenosine Triphosphate (ATP) to power cellular function. These mitochondrial ‘powerhouses’ of cells, also play roles in various aspects of cellular biology such as signalling, differentiation, cell cycle, growth and cellular death. (3)

The vital functions of the body are supported by key cellular nutrients, including:

ATP production: Vitamins and minerals act as cofactors in the biochemical pathways that generate ATP, which is the primary energy currency of cells. (4)
DNA repair: Certain nutrients support enzymes involved in repairing everyday DNA damage caused by metabolism, stress, and the environment. This helps preserve cellular integrity and healthy ageing. (5)
Cellular defence systems: Antioxidant nutrients like vitamin C, as well as B vitamins and trace minerals, help cells neutralise oxidative stress and maintain resilience against daily wear and tear. (6)

Spotlight on Key Nutrients

When it comes to cellular nutrition, a few nutrients stand out for the critical roles they play in energy, repair, and protection. Some of the most important are the B vitamins and Vitamin C.

A. Vitamin B Complex 

B vitamins are like the spark plugs of your metabolism. They don’t provide energy directly, but they help your cells unlock it from food. Each B vitamin plays a unique part, and together they support almost every major energy pathway in the body. (4)

  • Vitamin B1 (Thiamine) helps convert carbohydrates into usable energy.
  • Vitamin B2 (Riboflavin) supports the mitochondrial “power plants” that make ATP.
  • Vitamin B3 (Niacin) is a building block for NAD (nicotinamide adenine dinucleotide) and NADP, two compounds essential for metabolism
  • Vitamin B6, B12 and Folate play key roles in red blood cell formation, neurotransmitter balance, and DNA synthesis, as well as supporting protein metabolism.
  • Biotin plays a key role in the metabolism of fatty acids, glucose, and amino acids. Thus, supporting normal cellular function, growth and development.
  • Pantothenic Acid helps to synthesise coenzyme A (CoA) which plays a key role in oxidative metabolism.

Without enough of these essential cofactors, the body’s energy machinery cannot operate at full capacity

B. Vitamin C 

Vitamin C is best known for immune support, but its influence goes much deeper. Inside our cells, Vitamin C (7)

  • Acts as a powerful antioxidant, neutralising free radicals that can damage DNA and mitochondria.
  • Functions as a cofactor for enzymes that build collagen (for skin, joints, and blood vessels) and carnitine (needed for fat metabolism and energy production).
  • Supports the immune system, helping cells mount an effective defence when under stress.

Because our bodies can’t make or store much Vitamin C, daily intake is vital to keep cells protected and functioning optimally. (8)

Ensuring Optimal Cellular Nutrition

Even with the best intentions, getting all the nutrients your cells need—every single day—isn’t always easy. Modern lifestyles and dietary patterns can make it challenging to consistently hit the mark.

Nutrient gaps are common: Large population studies show that many adults fall short on key vitamins and minerals, particularly B vitamins and Vitamin C. According to UK. national survey data, significant portions of the population don’t meet daily requirements for several essential micronutrients. (9)

Modern diets aren’t what they used to be: Highly processed foods tend to be calorie-rich but nutrient-poor. At the same time, soil depletion and long food storage times can lower the vitamin content of fruits and vegetables. (10)

Lifestyle stress increases demand: Stress, pollution, alcohol, smoking, and even intense exercise can raise oxidative stress and deplete antioxidants like Vitamin C, as well as increase the need for B vitamins that support energy metabolism. (11,12) 

Conclusion 

Cellular nutrition is about more than simply “eating well”—it’s about giving your body the essential nutrients it needs to power energy production, repair and protect DNA, and defend against everyday stress. By focusing on key nutrients such as B vitamins and Vitamin C, we can help our cells perform at their best, supporting our health now and into the future. Yet, with modern diets, lifestyle stressors, and the natural changes that come with age, many people struggle to consistently meet these needs through food alone. That’s why a thoughtful approach to cellular nutrition—through diet and, when appropriate, supplementation—can be an important investment in long-term health.

 

This article was written by Caroline Hill who is a qualified dietitian with almost 20 years’ experience, having worked in the NHS and medical nutrition industry. She runs Caroline Hill Nutrition providing nutrition consultancy services to the food and medical nutrition industry, corporate wellness programmes and supporting 121 private clients. 

 

References:

1. Tourkochristou E, Triantos C, Mouzaki A. The Influence of Nutritional Factors on Immunological Outcomes. Front Immunol. 2021 May 31;12:665968.
2. Chen Y, Michalak M, Agellon LB. Importance of Nutrients and Nutrient Metabolism on Human Health. Yale J Biol Med. 2018 Jun 28;91(2):95-103
3. Kyriazis ID, Vassi E, Alvanou M, Angelakis C, Skaperda Z, Tekos F, Garikipati VNS, Spandidos DA, Kouretas D. The impact of diet upon mitochondrial physiology (Review). Int J Mol Med. 2022 Nov;50(5):135.
4. Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016 Jan 27;8(2):68
5. Ames BN. Micronutrients prevent cancer and delay aging. Toxicol Lett. 1998 Dec 28;102-103:5-18.
6. Liu Z, Ren Z, Zhang J, Chuang CC, Kandaswamy E, Zhou T, Zuo L. Role of ROS and Nutritional Antioxidants in Human Diseases. Front Physiol. 2018 May 17;9:477
7. Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017 Nov 3;9(11):1211.
8. Abdullah M, Jamil RT, Attia FN. Vitamin C (Ascorbic Acid) [Updated 2023 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK499877/
9. https://www.gov.uk/government/statistics/national-diet-and-nutrition-survey-2019-to-2023/national-diet-and-nutrition-survey-2019-to-2023-report
10. Bhardwaj RL, Parashar A, Parewa HP, Vyas L. An Alarming Decline in the Nutritional Quality of Foods: The Biggest Challenge for Future Generations' Health. Foods. 2024 Mar 14;13(6):877.
11. Sharifi-Rad M, Anil Kumar NV, Zucca P, Varoni EM, Dini L, Panzarini E, Rajkovic J, Tsouh Fokou PV, Azzini E, Peluso I, Prakash Mishra A, Nigam M, El Rayess Y, Beyrouthy ME, Polito L, Iriti M, Martins N, Martorell M, Docea AO, Setzer WN, Calina D, Cho WC, Sharifi-Rad J. Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases. Front Physiol. 2020 Jul 2;11:694
12. Alberts A, Moldoveanu E-T, Niculescu A-G, Grumezescu AM. Vitamin C: A Comprehensive Review of Its Role in Health, Disease Prevention, and Therapeutic Potential. Molecules. 2025; 30(3):748